The Chamber of St Matthews Kentucky Science Center Share: Non-Profit Organizations Kentucky Science Center Visit Website 727 W Main Street Louisville, KY 40202 (502) 561-6110 About Map About The official science center for the commonwealth of Kentucky. Kentucky Science Center encourages people of all ages to do science in engaging, educational, and entertaining ways to inspire a lifetime of learning. What's Nearby? Distance: 5 10 15 20 25 50 mi.